S2 hplc chromatograph for compound 1 elsd, 24% ch 3 cnh 2 o fig. Original article hepatoprotective activity of pien tze. Ahsan 4 1 department of pharmacology, mamc, new delhi, india. A number of natural tablets show promising hepatoprotective activities in acute and chronic liver damage. Further isolation of the active principles responsible for its hepatoprotective activity is currently in progress within our laboratory. Pdf liver diseases are a major worldwide health problem, with high endemicity in developing countries. Hepatoprotective activity of ethanol extract of pavetta. These systems measures the ability of the test drugs to prevent or cure liver toxicity induced by various hepatotoxins in experimental animals. The effect of a crude extract of the aerial parts of artemisia vulgaris av. There is a lack of reliable hepatoprotective drugs in modern medicine to prevent and treat druginduced liver damage. The extract exhibited significant hepatoprotective activity. Medicinal and aromatic plants research institute mapri, national center for research, khartoum, sudan. Antioxidant activity and hepatoprotective effect of an.
Ten groups of rats n 6 were given a oncedaily administration of 10% dimethyl sulfoxide negative control, 200 mgkg silymarin positive control, or memm 50, 250, or 500 mgkg for 7 days followed by induction of. Antioxidants free fulltext hepatoprotective effect of. Evaluation of the hepatoprotective activity of portulaca oleracea l. Hepg2 cells showed significant dose dependent increase in percentage viability at the doses 20, 40, 60, 80 and 100 gml of cpre compared to ccl 4 exposed hepg2 cells.
Malvaceae was examined for its hepatoprotective activity against liver damage induced by acetaminophen in rats. The hepatoprotective activity of the methanol extract was assessed in paracetamol induced hepatotoxic rats. On the other hand, andrographolide was found to weakly inhibit cyp3a4 activity 38. The results of the present study indicate that ethanol extract of o. Evaluation of hepatoprotective and antioxidant activity of ichnocarpus frutescens linn. The study was designed to evaluate the hepatoprotective activity of p. Antioxidant and hepatoprotective activity of ethanolic. The effects observed were compared with a known hepatoprotective agent, silymarin. Alteration in the levels of biochemical markers of hepatic damage like sgot. The ethanolic extract of the plant polygala elongata klein ex.
Phytochemistry and hepatoprotective activity of aqueous. The test material was found effective as hepatoprotective, through in vivo and histopathological studies. Hepatoprotective activity of ocimum sanctum alcoholic leaf. R siddhartha college of pharmaceutical sciences, vijayawada, andhra pradesh, india.
Pdf hepatoprotective activity of some plants extract. On day15 the hepatoprotective and antioxidant effects of eat were. Evidently, it may be stated that flavonoids of terminalia arjuna stem bark have hepatoprotective effect against ccl4 induced hepatic damage. Two novel trinorlanostanes, cochlates a and b 1 and 2, with a 3,4seco9,10seco9,19cyclo skeleton, as well as six new triterpenoids, fornicatins df 35 and ganodercochlearins ac 68, together with five known triterpenoids 9, were obtained from the fruiting bodies of ganoderma cochlear. Terminalia arjuna, stem bark, flavonoids, hepatoprotective activity. Hepatoprotective activity of aerial parts of otostegia persica against. Hepatoprotective activity of pien tze huang gan bao in ccl 4induced chronic liver injury models jinyan zhao 1,2, daxin chen, shan lin 1,2, yuchen zhang, yun wan, zhenfeng hong1. The aim of the study is to investigate the phytochemicals and hepatoprotective activity of melia azedarach l leaves extracts against carbon tetrachloride ccl 4 induced hepatotoxicity. Its hepatoprotective activity is attributed to its antioxidant properties.
The present study reports the investigation done on the hepatoprotective activity of ethanolic extract of mikania scandens l. A recent update on hepatoprotective potential of herbal plant. Evaluation of hepatoprotective activity of amoora rohituka. Hepatoprotection or antihepatotoxicity is the ability of a chemical substance to prevent damage to the liver. The structural elucidation was achieved by interpretation of spectroscopic data. Hepatoprotective activity of polygala elongata against. To investigate the hepatoprotective activity of ethanol extract of pavetta indica linn leaves. In acute toxicity studies, the extract when administered to mice as a single i. Around 170 phytoconstituents isolated from 110 plants belonging to 55 families have been reported to possess hepatoprotective activity. The test material was found effective as hepatoprotective. Pdf article info abstract liver is one of the largest and most vital organs in human body and the chief site for intense metabolism and. Amole tuber, cochlospermum vitifolium, heterotheca inuloides. The liver is indeed the main organ involved in metabolism and detoxification for the excretion of various endogenous and exogenous substances. Hepatoprotective activity of hepaxa polyherbal formulation ncbi.
The hepatoprotective activity of conyza bonariensis ethanol extract was studied against paracetamol induced hepatotoxicity in mice. The rats were divided into four groups, each group consisting of six animals. Here, we designed the experiments to examine the hepatoprotective activity of methanolic extract of leaves from underutilized c. Antioxidant and hepatoprotective activity of the aqueous. Dill anethum graveolens is an annual herb in the celery family apiaceae. The methanol extract of the fruit pulp of adansonia digitata l. Hepatoprotective activity of sachharum officinarum against paracetamol induced hepatotoxicity in rats. Evaluation of the hepatoprotective activity of fagonia cretica l. Evaluation of hepatoprotective activity of adansonia digitata. Phytochemical studies and hepatoprotective activity of melia. The aim of the study is to investigate the hepatoprotective activity of melia azedarach. Hepatoprotective activity, convolvulus pluricaulis, thioacetamide, alt, ast and bilirubin. Evaluation of hepatoprotective activity of aqeous leaf.
Antioxidant and hepatoprotective activity of ethanol extract of valeriana wallichii in ccl 4 treated rats s. Investigation of hepatoprotective activity of cyathea gigantea wall. A recent update on hepatoprotective potential of herbal plant mohammad irfan ali1 and manoj kumar2 1school of sciences, suresh gyan vihar university, jaipur302017, rajasthan, india 2marine biotechnology laboratory, department of botany, university of delhi, north campus, india corresponding authoremail. It is a nontoxic hepatoprotective substance from the himalaya drug co. Hepatoprotective activity of methanol extract of melastoma. Hepatoprotective activity of hepax was studied against three experimentally induced hepatotoxicity models, namely, carbon tetrachloride ccl4, paracetamol. A major project report on evaluation of hepatoprotective activity of amoora rohituka submitted to rajiv gandhi proudyogiki. The antioxidant and hepatoprotective actions of terminalia catappa l. Hepatoprotective activity of the chloroform extract of the shade dried aerial parts of solanum trilobatum linn.
Hepatoprotective effect of leaf extracts from citrus hystrix. Review of plants with hepatoprotective activity evaluated in mexico. To investigate the hepatoprotective activity of methanolic leaf extract of cyathea gigantea c. Three new sesquiterpenes and two new rutinosides 4 and 5 along with 17 known compounds 622 were isolated from the leaves of murraya koenigii l. Models of hepatoprotective activity assessment medicina. Hepatoprotective activity of the ethanolic extract of ficus. The hepatoprotective and antioxidant activity of silymarin is caused by its ability to inhibit the free. Hepatoprotective activity of solanum trilobatum linn. These conditions can be cured with hepatoprotective agents. This is opposite to hepatotoxicity hepatoprotective molecules used in emergency medicine. The hepatoprotective activity, which is seen at the highest concentration 10 mlkg of vcos used, was also accompanied by the vcos ability to reduce pcminduced increase in body and. In an attempt to further establish the pharmacological properties of bauhinia purpurea fabaceae, hepatoprotective potential of methanol extract of b. Male albino rats weighing between 150 and 175 g were used as animal models. Metabolic profile and hepatoprotective activity of the.
The hepatoprotective activity of hsare was assessed 100mgkgd for 4 weeks by examining the hepatic, inflammatory, oxidative stress markers and performing a histopathological. The present study aimed to determine the hepatoprotective activity of a methanol extract of melastoma malabathricum leaves memm using two established rat models. Coldenia procumbens linn, isoniazid, pyrazinamide, rifampicin, mtt assay. In vitro hepatoprotective activity of terminalia arjuna. Hepatoprotective activity of parmelia perlata huds. This study investigated the hepatoprotective effects of aqueous leaf extract of swietenia mahogany maliaceae in chronic alcoholinduced liver injury in rats. Hala salah eldin, haidar abdal gadir, abdel wahab hassan. Hepatoprotective activity of the leaves of nyctanthes arbor. Oct 25, 2019 lycopene hepatoprotective pdf bisphenol a bpaan endocrine disruptor xenoestrogenis widely spread in the environment. Evaluation of the hepatoprotective activity of fagonia. Hepatoprotective effect of silymarin pubmed central pmc.
Hepatoprotective activity of chitosan nanocarriers loaded. Hepatoprotective effects of triterpenoids from ganoderma cochlear. Evaluation of hepatoprotective activity of aqeous leaf extract of swietenia mahogani maliaceae in chronic alcoholinduced liver injury in rats. Some have been analyzed and scientifically validated for their potentials. Hepatoprotective activity of chhitchanthan extract powder against carbon tetrachlorideinduced liver injury in rats. The extract was found to be effective in shortening the. Green tulsi ocimum sanctum, belonging to family lamiaceae are used traditionally for their hepatoprotective effect. Significant hepatoprotective activity of ocimum sanctum was reported earlier against paracetamol, carbon tetrachloride and antitubercular druginduced hepatoxicity in albino rats. Prabhakaran v, srinivas ashok kumar b, sheshadri shekar d, nandeesh r, subramanyam p and ranganayakulu d.
Hepatoprotective diterpenoids isolated from andrographis. Hepatoprotective activity of ethanol extract of conyza b. The animals were divided in to five groups of six animals each and maintained on standard the leaves of nyctanthes arbortristis were collected from diet and water, ad libitum. Dixit, neelesh malviya and vijay ambawatia department of pharmacognosy, smriti college of pharmaceutical education, dewas naka, indore, madhya pradesh 452010 india. The liver is indeed the main organ involved in metabolism. Phytochemical studies and hepatoprotective activity of melia azedarach linn, against ccl 4 induced hepatotoxicity in rats mohammed fazil ahmed1, a. Hepatoprotective activity of some indigenous plants. Hepatoprotective activity of ocimum sanctum alcoholic leaf extract. Hence, it was proposed to carry out a preliminary in vitro analysis of the hepato protective activity of the plant, which gave promising results.
Willd ms and its ethyl acetate and nhexane fractions in isoniazid. On account of this fact, investigations aiming to obtain natural andor synthetic compounds possessing hepatoprotective activity have been undertaken. Hepatoprotective activity of chhitchanthan extract powder against. About 600 commercial herbal formulations with hepatoprotective activity are being sold all over the world. Bacteria associated with the red sea sponge amphimedon ochracea in ccl 4 induced hepatotoxicty in rats.
Hepatoprotective activity of methanolic extract of bauhinia. The hepatoprotective activity of eeih might be attributed to the flavonoid compounds such as catechin 1, 3. Sumalatha, suhani and padma, divya and pai, sreedhara kr and kotian, sushma r and kumar, nitesh and bhat, kumar mr 2016 hepatoprotective activity of aqueous extract of. Hepatoprotective activity of melia azedarach leaf extract. Glucoselowering, hepatoprotective and hypolipidemic. Evaluation of hepatoprotective and antioxidant activity of. Parmar and others published hepatoprotective activity of some plants extract against paracetamol induced hepatotoxicity in wistar rats find, read and cite all the. Keeping this in view, the present study has been undertaken to investigate hepatoprotective activity and antioxidant role of the chloroform and. A major project report on evaluation of hepatoprotective activity of amoora rohituka submitted to rajiv gandhi proudyogiki vishwavidyalaya in partial fulfillment of the requirement for degree of master in pharmacy pharmacology, bhopal submitted by shailly malviya supervisor cosupervisor dr. The chemical composition of six essential oils eos of thymus serrulatus and thymus schimperi from six localities in ethiopia, namely ofla, alamata, yilmana densa, tarmaber, butajira and bale was determined.
Manokaran s, jaswanth a, sengottuvelu s, nandhakumar j, duraisamy r, karthikeyan d, et al. Alteration in the levels of biochemical markers of hepatic damage like sgot, sgpt, alp. Antioxidant and hepatoprotective activity of ethanol extract. Phytochemical studies and hepatoprotective activity of. The phytochemical screening was carried on the leaves extracts of melia azedarach revealed the presence of some active. Thus the antioxidant activity of the ethanolic extract may be due to the presence of flavonoid and phenolic compounds. Composition and hepatoprotective activity of essential. Hepatoprotective sesquiterpenes and rutinosides from. The hepatoprotective activity was also supported by histopathological studies of liver tissue. To evaluate the hepatoprotective effect and study the metabolic profile of the anthocyaninrich extract of h. Willd polygalaceae was lnvesti gated for its hepatoprotective activity in male wistar rats. Both in vitro and in vivo liver models have been developed in the past years to study the hepatoprotective agents.
Supporting information coumarin analogues from the citrus. In order to identify the molecular mechanism involved in the hepatoprotection of ifc305 in ccl 4induced cirrhosis in rats, we extended our studies to analyze the effect of the compound on the. We wanted to evaluate the hepatoprotective activity. This antioxidant activity is manifested by free radical scavenging 9 10, which can confer a hepatoprotective effect 7 8 11. Invitro analyses such as phenolic and flavonoid contents, antioxidant activity were done using standard spectrophotometric method and invivo antioxidant activity. This plant contains at least seven flavoligands and the flavonoid taxifolin. The principle depends on the fact that administration of acetaminophen will be associated with development of oxidative stress. Sai sruthi arige, sai datri arige and lakshmana rao, a. The full text of this article is available in pdf format. Melia azedarach, hepatoprotective activity, simvastatin, ethanol and silymarin. Antioxidant and hepatoprotective activity of garlic chives. Antiinflammatory and hepatoprotective activities of. Hepatoprotective activity of aqueousmethanol extract of.
Hepatoprotective potentials of aqueous extract of convolvulus. This is the first report of the hepatoprotective activity of the plant. Among the medicinal plants, myrtus communis family. Hepatoprotective activity of methanol extract of some. The hepatoprotective activity of frp and frae was assessed by measuring the activity of serum transaminases ast and alt. Galn and lipopolysaccharide lps induced hepatitis in mice. International journal of integrative sciences, innovation and technology 20. The effects observed were compared with a known hepatoprotective. Shristi badhani, shivani sharma, amrita kainth, bharat parashar department of pharmacy, manav bharti university, solan, h.
Hepatoprotective activity of aeschynomene aspera linn. Cleome viscosa linn tickweed the hepatoprotective activity of the cleome viscosa linn capparidaceae extract was assessed in cci 4 induced hepatotoxic rats. In vitro and in vivo hepatoprotective activity of cissampelos. Group one was kept on normal diet and served as control, the second. In addition, hepatospecific serum markers will be disturbed. Antioxidant and hepatoprotective actions of medicinal herb. Hepatoprotective activity of the lichen usnea ghattensis has been established in vitro verma et al.
1410 938 1277 1344 457 656 1302 497 1243 149 375 888 765 473 19 346 436 74 1162 1057 1203 1493 963 800 115 38 45 1023 957 307 1223 1453 1356 998 331 1257